期刊论文详细信息
Iranian journal of reproductive medicine | |
ULTRASTRUCTURAL AND MORPHOMETRICAL STUDY OF PREIMPLANTATION ENDOMETRIUM IN SUPEROVULATED MICE TREATED WITH PROGESTERONE OR SILDENAFIL | |
MAZOCHIAN HOSSEIN1  ROSHANGAR LEILA1  SOLEIMANI RAD SARA1  SOLEIMANI RAD JAFAR1  NIKZAD BEHZAD1  RASHIDI BAHMAN1  | |
关键词: IMPLANTATION; PROGESTERONE; SILDENAFIL; MICE; UTERINE; | |
DOI : | |
学科分类:药学、药理学、毒理学(综合) | |
来源: Shahid Sadoughi University of Medical Sciences, Yazd | |
【 摘 要 】
Background: Endometrial development has an important role in blastocyst adhesion and implantation. During IVF cycles, endometrial development is enhanced by progesterone.Objective: The aim of this study was to compare ultrastructural and morphometrical characteristics of mice uterine endometrium in natural cycle with those in superovulated cycles received progesterone or Sildenafil.Materials and Methods: In This study, 60 female bulb/c mice were divided into 4 groups: a control and 3 experimental; gonadotropin, gonadotropin+ Sildenafil and gonadotropin+ progesterone. In experimental groups the mice superovulated mated. In the gonadotropin+ progesterone and gonadotropin+ Viagra groups, the mice respectively received 1mg progesterone and 3 mg Sildenafil citrate. Their uterine specimens were prepared for morphometrical and ultrastructural study. Height of the epithelial cells was measured, using motic software. Statistical analysis was performed using ANOVA.Results: Microscopy revealed that in control group the cells had numerous apical microvilli and the height of the cells was 20.52±2.43【 授权许可】
Unknown
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RO201912010273086ZK.pdf | 545KB | download |