EVALUATION OF SERUM CREATINE PHOSPHOKINASE IN DIAGNOSIS OF TUBAL ECTOPIC PREGNANCY COMPARED WITH INTRAUTERINE PREGNANCY AND THREATENED ABORTION

Iranian journal of reproductive medicine

PARVIZI AYDA¹  ATRKAR ROSHAN ZAHRA¹  FARAJI ROYA¹  ASGHARNIA MARYAM¹  MIRBLOOK FARIBA¹ 

关键词: CREATINE PHOSPHOKINASE;    TUBAL ECTOPIC PREGNANCY;    THREATENED ABORTION;    INTRAUTINE PREGNANCY;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Vaginal sonograghy and serial b-hCG are the most common diagnostic methods for ectopic pregnancy but about 50% of cases are initially misdiagnosed. In tubal pregnancy the zygote lies next to the muscular layer, and this invasion causes an increase in creatine phosphokinase (CPK) in blood.Objective: assessment of CPK and its isoenzyme CPK-MB as a diagnostic marker for tubal pregnancy.Materials and Methods: In this case-control study, 111 women between 16-40 years in first-trimester pregnancy admitted to emergency ward of Rasht Alzahra hospital with abdominal pain or vaginal bleeding were included and according to sonography and bCG divided into 3 groups (N=37): tubal pregnancy (1), threatened abortion (2) and normal pregnancy (3). Blood samples were taken for totalCPK and CPK-MB before any invasive procedure.Results: Mean total CPK level were 96.27±63.9 u/lit (group 1), 55.37±14.1 u/lit (group 2) and 48.94±19.2 u/lit (group 3) and was significantly higher in tubal pregnancy compared to other groups. Mean CPK-MB levels in 3 groups were 15.62±5.2 u/lit, 17.32±6.9 u/lit, and 15.1±4.7 u/lit, respectively which was not significant.Conclusion: It seems that determination of total CPK can enhance the diagnostic value of tubal pregnancy.

【 授权许可】

Unknown