DOES INHIBIN-B HELP US TO CONFIDENTLY REFUSE DIAGNOSTIC TESTICULAR BIOPSY IN AZOOSPERMIA?

Iranian journal of reproductive medicine

PARHODAH FARAJOLLAH¹  MORADI MAHMOUDREZA¹  IIZADI BABAK¹  TORKAMAN ASADI FATEMEH¹  MORADI ASAAD¹  ALEMI MOHSEN¹ 

关键词: INFERTILITY;    HISTOLOGY;    SPERM CELL;    GERM CELL;    DIAGNOSIS;    AZOOSPERMIA;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: In the recent years, the use of laboratory blood factors such as FSH and inhibin-B for the assessment of spermatogenesis in different studies has increased; of course, the conflicting results have also been achieved.Objective: To investigate if the measurement of inhibin-B can help surgeon to reduce unnecessary diagnostic testicular biopsies in males with azoospermia.Materials and Methods: This cross-sectional study was done during July 2006 to September 2007 on 41 patients with azoospermia. FSH and inhibin-B were measured and bilateral open testicular biopsy was performed for all patients.Results: Sperm was seen in 29% of biopsies that in 100% of these samples inhibin-B was more than 100 pg/mL and FSH was less than twice the normal (p=0.001). Inhibin-B had significant correlation inversely with testicular fibrosis and Sertoli cell only syndrome (p=0.043 and p=0.011, respectively) and directly with incomplete spermatocytic maturation arrest and obstructive azoospermia (p=0.027 and p=0.013, respectively). FSH was only correlated with obstructive azoospermia (p=0.001).Conclusion: We suggest that if FSH is less than twice the normal, inhibin-B should be measured and if its level is less than 100 pg/mL, we can cancel about the half of unnecessary diagnostic testicular biopsies.

【 授权许可】

Unknown