EFFECT OF LITHIUM CHLORIDE ON THE LUTEAL STEROIDOGENESIS IN GONADOTROPIN-STIMULATED RAT

Iranian journal of reproductive medicine

BASAVAIAH SHIVA¹  ABEDIAN KENARI SAEID¹  KHODADADI MARYAM¹ 

关键词: LUTEAL STEROIDOGENESIS;    LITHIUM CHLORIDE;    CORPUS LUTEUM;    PROGESTERONE;    ESTRADIOL;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Main function of corpus luteum is progesterone synthesis that is significantly accompanied with an increase in levels of mRNA encoding of steroidogenic enzymes known as luteal markers.Objective: This study was designed to evaluate effects of lithium chloride on the release of steroid hormones and steroidogenic enzymes in gonadotropin-stimulated rats.Materials and Methods: Immature 23 days old Wistar rats were divided into 10 groups; each group comprised of 8 rats, and induced with single injection of pregnant mare’s serum gonadotrophin (PMSG) and followed by single injection of human chorionic gonadotropin (hCG). Then, rats were given lithium chloride (LiCl) or saline at 12 hours post-hCG injection. Ovaries were collected in 4-hour interval from 8-24 hour post-hCG injection. Expression pattern of steroidogenic acute regulatory protein (StAR), side-chain cleavage cytochrome P450 (P450scc) and 3

【 授权许可】

Unknown