EVALUATION THE FREQUENCY OF FACTOR V LEIDEN MUTATION IN PREGNANT WOMEN WITH PREECLAMPSIA SYNDROME IN AN IRANIAN POPULATION

Iranian journal of reproductive medicine

AZIZI KOOTENAEE MARYAM¹  AZINFAR AZADEH¹  KARIMI SAMIEH¹  RAJAEI MINOO¹  YAVARIAN MAJID¹ 

关键词: PREECLAMPSIA;    FACTOR V LEIDEN MUTATION;    OBSTETRIC COMPLICATION;    IRAN;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Role of genetic factors in etiology of preeclampsia is not confirmed yet.Objective: Gene defect frequency varies in different geographic areas as well as ethnic groups. In this study, the role of factor V Leiden mutation in the pathogenesis of preeclampsia syndrome among the pregnant population of northern shore of Persian Gulf in Iran, were considered.Materials and Methods: Between Jan.2008 and Dec.2009, in a nested case control study, pregnant women with preeclampsia (N=198) as cases and healthy (N=201) as controls were enrolled in the study. DNA were extracted from 10 CC peripheral blood and analyzed for presence of factor V Leiden mutation in these subjects. The maternal and neonatal outcomes of pregnancy according to the distribution of factor V Leiden were also compared among cases.Results: In total, 17 (8.6%) of cases and 2 (1%) of controls showed the factor V Leiden mutation.The incidence of factor V Leiden was typically higher in preeclamptic women than control group (OR: 9.34 %95 CI: 2.12-41.01). There was no difference in incidence rate of preterm delivery<37 weeks (OR: 1.23 %95 CI: 0.38-4.02), very early preterm delivery<32 weeks (OR: 1.00 %95 CI: 0.12-8.46), intra uterine fetal growth restriction (IUGR) (OR: 1.32 %95 CI: 0.15-11.30 ), and the rate of cesarean section (OR: 0.88 %95 CI: 0.29-2.62) among cases based on the prevalence of factor V Leiden mutation.Conclusion: The pregnant women with factor V Leiden mutation are prone for preeclampsia syndrome during pregnancy, but this risk factor was not correlated to pregnancy complications in the studied women.

【 授权许可】

Unknown