HIGH PLASMA HOMOCYSTEINE AND INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

Iranian journal of reproductive medicine

DAVARI TANHA FATEMEH¹  HEMATI TAYEBE¹  MOGHADAMI TABRIZI NASRIN¹  JAVADIAN POUYA¹  SALMANIAN BAHRAM¹ 

关键词: PCOS;    HOMOCYSTEINE;    INSULIN RESISTANCE;    INFERTILITY;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Polycystic ovarian syndrome (PCOS) is a common disease among women in fertility ages and cause severe insulin resistance. Hyperhomocysteinaemia is said to be among the features of PCOS that could influence its outcome.Objective: This study aimed to investigate whether hyperhomocysteinaemia exists in PCOS and if it is related to insulin resistance in the affected patients.Materials and Methods: This prospective study was carried out in a university based fertility clinic. Sixty four PCOS patients and 50 normo ovulatory controls were reviewed for fasting glucose, insulin, homocysteine, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) plasma levels in the blood sample of the 3rd day of their menstrual cycle. Insulin resistance was determined with the fasting glucose (mmol/L) to insulin (mIU/L) ratio and HOMA-IR (Homeostasis model assessment-Insulin resistance). Independent-samples T-test and linear regression test were utilized to analyze the obtained data.Results: Homocysteine levels compared between PCOS patients and control group showed a significant difference. PCOS group was divided into insulin resistant (IR) (LogHOMA-IR³

【 授权许可】

Unknown