ICODEXTRIN REDUCES ADHESION FORMATION FOLLOWING GYNECOLOGICAL SURGERY IN RABBITS

Iranian journal of reproductive medicine

MEHRABIAN FERDOUS¹  BAHRAMI NAHID¹  NADERI NAENI HORMOZ¹  KHANI BEHNAZ¹ 

关键词: ICODEXTRIN SOLUTION;    HUMAN AMNIOTIC FLUID;    ADHESION FORMATION;    RABBIT;   

DOI  :  

学科分类：药学、药理学、毒理学（综合）

来源: Shahid Sadoughi University of Medical Sciences, Yazd

【 摘 要 】

Background: Adhesion is a common complication of gynecology surgery so different barrier agents and solutions have been used during these operations to separate and protect tissues from adhesion after surgery. Adept is one of these solutions that have been postulated to reduce the chance of adhesion following gynecolgy surgery.Objective: To evaluate the effect of 4% icodextrin in reducing adhesion formation in comparing with sterile water and human amniotic fluid in rabbits.Materials and Methods: In this prospective experimental study 30 white Newzealand female rabbits were selected and randomized in to three treatment groups. The rabbits were anesthetized and an abdominal incison was made, uterine horns were abrated with gauze until bleeding occurred. Before closing the abdomen, the traumatized area was irrigated either by 30cc of sterile water, 30cc of 4% Adept or 30cc of human amniotic fluid. The solutions were labeled only as solutions A (steriel water), B (icodextrin), or C (human amniotic fluid). On the seventh day after surgery, second laparotomy was performed to determine and compare adhesion formation in rabbits.Results: There was significant difference between mean score of adhesions in 4% icodextrin group (2.1

【 授权许可】

Unknown