Investigation of the Association Between 584C/T Polymorphism of EL Gene and Risk of Premature Coronary Artery Disease in Fars Province

Journal of Cardiovascular and Thoracic Research

Salma Radmanesh²  Sara Senemar¹  Samane Toosi¹  Zeinab Ahmadi¹ 

[1] Human Genetic Research Group, Iranian Academic Center for Education, Culture & Research (ACECR), Fars Branch, Shiraz, Iran$$;Department of Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran$$

关键词: Coronary Artery;    Endothelial Lipase;    Polymorphism;    584C/T;   

DOI  :  10.15171/jcvtr.2015.25

学科分类：农业科学（综合）

来源: Tabriz University of Medical Sciences and Health Services

【 摘 要 】

Introduction: Endothelial lipase (EL) is a protein from the triglyceride lipase family which plays an important role in high-density lipoprotein (HDL) metabolism. One of the most frequently studied variants is 584C/T which causes the amino acid threonine at codon 111 to convert to isoleucine. Many studies have shown the association of this variant with HDL-C level and CAD disease.Methods: The population of this study consists of 140 patients (all males) with angiographically confirmed coronary artery disease (CAD) and 80 controls. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) was carried out for genotyping of LIPG 584C/T. Data were analyzed using SPSS.Results: The results of the study indicated that the frequency of T allele was significantly lower among CAD patients than among controls (0.27 vs 0.36, P = .004). However, no significant correlation was found between the 584C/T variant and serum HDL-C level. Multivariate regression analysis confirmed that the T allele is significantly associated with CAD disregarding the age, hypertension, hypercholesterolemia, diabetes and HDL-C (OR = 0.494, 95% CI = 0.253-0.968, P =.040).Conclusion: It was concluded that the T allele was associated with protection from CAD in Fars province independent of HDL-C level.

【 授权许可】

Unknown