Homocysteine Level According to Some Cardiac Risk Factors and Extent of Coronary Disease

Journal of Cardiovascular and Thoracic Research

Mohammad Kiani¹  Nouraddin Mousavinasab¹  Sepideh Sokhanvar¹  Zahra Golmohammadi² 

[1]Department of Cardiology, Zanjan University of Medical Sciences, Zanjan, Iran.$$

[2]Cardiovascular ResearchCenter, Tabriz University ofMedical Sciences, Tabriz, Iran.$$

关键词: Homocysteine;    Coronary artery dsease;    Risk factor;   

DOI  :  

学科分类：农业科学（综合）

来源: Tabriz University of Medical Sciences and Health Services

【 摘 要 】

Hyperhomocysteinemia is accompanied by many cardiovascular risk factors. Howeverit’s relation with other cardiac risk factors and with extent of coronary artery disease(CAD) is still a controversial issue. This study was designed to investigate therelationship between total plasma homocysteine (tHcy) levels and other cardiovascularrisk factors and the severity of CAD. Fasting plasma tHcy levels were measured in 60patients with angiographically documented CAD and compared to 56 control subjectsmatched for age, sex, and smoking habits. Also patients were classified into two groups oflow risk (with two or few risk factor) and high risk (with three and more risk factor)according to their major risk factors. Mean of tHcy levels were significantly higher inhigh risk patients compared to low risk patients (p=0.013). Also hyperhomocysteinemiarate was higher in the high risk patients compared to low risk patients, OR=5 (CI95%=1.6-16).There was relationship between coronary risk factors and severe coronaryartery disease (three vessels disease) but this relationship was statistically significant onlyin smokers (P=0.012) and diabetic patients (P=0.035) . Plasma tHcy level was anindependent risk factor for high risk patients.

【 授权许可】

Unknown