Evaluation of hs-CRP, Antioxidant Markers andMDA in Patients of CoronaryArtery Disease (CAD) Containing Non-Smokers and Non-Diabetics

Journal of Cardiovascular and Thoracic Research

Hossein Babaie²  Mohammad Rahbani³  Nosratollah Zarghami³  Fatemeh Khaki Khatibi³  Alireza Yaghoubi¹ 

[1] Cardiovascular ResearchCenter, Tabriz University ofMedical Sciences, Tabriz, Iran.$$;Radiopharmaassay Lab, Drug Applied Research Center and Development Complex, Tabriz University of Medical Sciences. Tabriz, Iran.$$;Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences. Tabriz, Iran.$$

关键词: Antioxidant;    Oxidative stress;    Coronary Artery Disease;    Inflammation;    Nonsmoker;    Nondiabetic;   

DOI  :  

学科分类：农业科学（综合）

来源: Tabriz University of Medical Sciences and Health Services

【 摘 要 】

Background: The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. In thepresent study we assessed the association of MDA, antioxidant markers, high sensitive C - reactive protein (hs-CRP) andlipid status parameters in the patients with coronary artery disease (CAD). Significant risk factors such as cigarette anddiabet were excluded from the study.Methods: Oxidative stress parameters for example Malondialdehyde (MDA), antioxidant markers including: erythrocytesuperoxide dismutase(SOD), Glutathion peroxidase (GPX), Total antioxidant capacity(TAC), The inflammation marker andserum lipid status parameters were measured in 120 subjects including 60 CAD patients with angiographically diagnosedCAD and 60 CAD-free subjects as a control group, also diabetics, smoking patients, patients with malignancy, renal andliver disease, and other disease were excluded from the study.Results: The serum MDA and hs-CRP levels were increased significantly as compared to controls. However, erythrocyteSOD, GPX activities and TAC level were reduced significantly in patients (P�?0.05 in all cases). The levels of totalcholesterol, Triglyceride, LDL-C were significantly higher and that of HDL-C was meaningfully lower than those ofcontrol (P�?0.05 in all cases).Conclusion: The association between oxidative stress parameters, antioxidant markers, the inflammation index and lipidstatus parameters suggest their involvement in atherosclerosis development that may lead to CAD progression

【 授权许可】

Unknown