When the gut leaks

Malta medical journal

Edgar Pullicino¹ 

关键词: Tight junctions;    permeability;    paracellular;    diarrhoea;    zonulin;   

DOI  :  

学科分类：医学（综合）

来源: University of Malta * Medical School

【 摘 要 】

Aspects of the structure, molecular biology and control of the tight junctions that regulate paracellular transport by the small intestine are reviewed so as to understand the limitations of intestinal permeability as a bedside tool to investigate diarrhoea. Examples of the altered structure and behaviour of tight junctions during abnormal permeability are used to gain insight into the pathogenesis of diarrhoeal diseases and potential new therapies.

【 授权许可】

Unknown