Molecular mechanisms in haematological malignancies

Malta medical journal

Pierre Schembri Wismayer¹  Godfrey Grech¹  Roberto Avellino¹ 

关键词: Haematopoiesis;    haematological malignancies;    leukaemia;    cytogenetic aberrations;    transcription factors;    molecular genetics;   

DOI  :  

学科分类：医学（综合）

来源: University of Malta * Medical School

【 摘 要 】

Haematopoiesis requires the constant production of large numbers of peripheral blood cells. This process is under tight control of transcription factor networks as well as cytokines,growth factors and hormones. We will review the importance of transcription factors in programming thehaematopoietic lineage commitment and the role of the microenvironmentand the corresponding cellular sensitivity to ensure productionof mature functional cells in response to the physiological demand. Understanding the molecular mechanism of this complex process gives the opportunity to identify the underlyingmolecular deregulation in haematopoietic malignancies. The different levels of deregulationinclude hyperproliferation, block in differentiation and sensitivity to growth factors. In this review,leukaemic transformation is selected to give evidence of cell signallingderegulation. The clinical implications will be reviewed in the context of the potential opportunities in the future to identify specific therapeutic patient groups that can be defined using prognostic and predictivebiomarkers.

【 授权许可】

Unknown