Malta medical journal | |
Swollen Limbs and Bone Pain: A Case Report | |
Joseph M Cacciottolo1  David Sammut1  Miguel Debono1  | |
关键词: ACTH syndrome; ectopic; carcinoma; small cell; case report cushing's syndrome; hypokalaemia; lung neoplasms; osteomalacia; paraneoplastic syndromes; | |
DOI : | |
学科分类:医学(综合) | |
来源: University of Malta * Medical School | |
【 摘 要 】
A 50 year old man presented with peripheral oedema, abdominal distension and a pulmonary opacity on CXR. He subsequently perforated his sigmoid colon as a complication of diverticulitis with pericolic abscess. After colectomy his postoperative period was marked by severe hypokalaemia, metabolic alkalosis, hyperglycaemia and recurrent chest infections. Paraneoplastic Cushing`s syndrome was diagnosed after finding elevated serum cortisol and ACTH levels. CT-guided biopsy of the lung lesion revealed small-cell carcinoma. Bone scan disclosed collapse of numerous thoracic vertebrae possibly due to osteoporosis or oncogenic osteomalacia. Treatment with steroid-synthesis blockers was commenced but the patient died before tumour-directed therapy could be started. Ectopic ACTH syndrome and oncogenic osteomalacia are discussed.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010261991ZK.pdf | 122KB | download |