Malta medical journal | |
The Hepatitis C Virus: Your Part in its Downfall Getting to know the Virus and its Host | |
Edgar Pullicino1  | |
关键词: Hepatitis C; quasispecies; genotypes; viraemia; cirrhosis; fibrosis; transaminase; | |
DOI : | |
学科分类:医学(综合) | |
来源: University of Malta * Medical School | |
【 摘 要 】
The cloning of the genome of the Hepatitis C virus (HCV) in 1989 provided sensitive screening tools and specific diagnostic assays which helped health workers to limit viral spread and scientists to design effective anti-viral agents. The uncorrected intrinsic error rate of HCV`s key replicating enzyme (RNAdependent RNA polymerase) leads to antigenically different`"quasispecies" which allow the virus to escape immune recognition by the host and leads to an ill-sustained clearance of virus by T lymphocytes. This article discusses the factors which may lead to progressive liver fibrosis and provides a theoretical framework for the selection of patients for viral eradication using pegylated preparations of recombinant interferon in conjunction with the oral antiviral ribavarine.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010261984ZK.pdf | 71KB | download |