Imaging features of renal complications after crizotinib treatment for non–small-cell lung cancer: a case report

Developmental Biology

Mei-Kim Ang²  Wan Lin Koh¹  Daniel Shao Weng Tan²  Jin Wei Kwek³  Wan Ying Chan³ 

[1] Asiamedic Limited, Singapore$$;Division of Medical Oncology, National Cancer Centre, Singapore$$;Division of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, 169610 Singapore$$

关键词: Crizotinib;    Non–small cell lung cancer;    ALK inhibitor;    Renal cysts;   

DOI  :  10.1016/j.radcr.2016.04.010

学科分类：医学（综合）

来源: University of Washington * Department of Radiology

【 摘 要 】

Crizotinib has been approved for the treatment of advanced ALK-positive non–small cell lung cancer. Its use is associated with the development of complex renal cysts. However, there is limited literature regarding imaging features of renal cystic disease during crizotinib therapy and its complications or progression. Here, we describe a case of a patient with ALK-positive advanced non–small cell lung cancer who developed complex renal cyst during crizotinib treatment. The renal cyst is complicated by infection and abscess formation. Subsequent renal biopsy, antibiotics treatment, and open drainage of loculated renal abscess showed no malignant cells and contributed to the diagnosis. The imaging features should be recognized as renal cystic disease of crizotinib treatment and not to be mistaken as new metastasis and disease progression.

【 授权许可】

Unknown