Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine

Acta Naturae

S. M. Zakian¹  S. P. Medvedev¹  A. I. Shevchenko¹ 

关键词: cell reprogramming;    induced pluripotent stem cells;    directed stem cell differentiation;    cell replacement therapy;   

DOI  :  

学科分类：生物技术

来源: Moskovskii Gosudarstvennyi Universitet im.M.V.Lomonosova/M.V.Lomonosov Moscow State University

【 摘 要 】

ESCs �? embryonic stem cells; iPSCs �? inducedpluripotent stem cells; Chd1 �? chromodomain helicase DNA-binding protein; BAF �?rg/Brahma-associated factors; miRNA, miR �? microRNA; TERRA �?telomeric-repeat-containing RNA; Cdkn �? cyclin-dependent kinase inhibitor; VPA�? valproic acid; siRNA �? small interfering RNA; KMOS �? Klf4, c-Myc, Oct4, Sox2;KOS �? Klf4, Oct4, Sox2; LNOS �? Lin28, Nanog, Oct4, Sox2; GSK-3 �? glycogensynthase kinase 3; ROS �? reactive oxygen species; HIF1 �? hypoxia-induciblefactor 1; VEGF �? vascular endothelial growth factor.

【 授权许可】

Unknown