Closing the knowledge gap on cardiovascular disease in type 2 diabetes: the EMPA-REG OUTCOME trial and beyond

Drugs In Context

Elif A Oral¹ 

关键词: cardiovascular disease;    empagliflozin;    glucose-lowering;    heart failure;    major adverse cardiovascular events;    sodium glucose cotransporter 2 inhibitor;    type 2 diabetes mellitusw;   

DOI  :  10.7573/212299

学科分类：医学（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

AbstractType 2 diabetes mellitus (T2DM) is associated with marked cardiovascular (CV) morbidity and mortality, including heartfailure (HF). Until recently, an oral glucose-lowering agent that improved hyperglycemia as well as provided CV benefits in patients with T2DM and  cardiovascular disease (CVD) was lacking. The newest class of glucose-lowering agents, sodium glucose cotransporter 2 (SGLT2) inhibitors, includes canagliflozin, dapagliflozin, and empagliflozin. Prior to the release of the LEADER trial results, the recent EMPA-REG OUTCOME study was the only dedicated CV trial to demonstrate a reduction in major adverse cardiac events, CV mortality, and all-cause mortality and a reduction in hospitalization for HF with empagliflozin, given on top of standard-of-care therapy in patients with T2DM and CVD. This paper summarizes the results from EMPA-REG OUTCOME and discusses their significance and clinical implications.

【 授权许可】

Unknown