Managing insomnia: an overview of insomnia and pharmacologic treatment strategies in use and on the horizon

Drugs In Context

Thomas L Schwartz¹  Viral Goradia¹ 

关键词: Hypnotic agents;    Insomnia;    Neurology;    Psychiatry;   

DOI  :  10.7573/dic.212257

学科分类：医学（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

This review explores basic sleep physiology, the mechanism of action for each class of hypnotic agents, their clinical application based on pharmacodynamic and pharmacokinetic factors, and potential pharmacologic sleep-inducing mechanisms of future hypnotics. The paper challenges the reader to understand the neuroscientific basis of insomnia and use this knowledge to guide prescription of hypnotic agents. Currently indicated hypnotic agents are discussed with regard to their mechanism of drug action and clinical application. A broader discussion is developed throughout this paper regarding other non-indicated agents that may improve sleep and describing newer pharmacological treatments that may become available in the future for use in sleep disorders and their comorbid conditions.

【 授权许可】

Unknown