Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Quantitative Imaging in Medicine and Surgery

Ruikang K. Wang¹  Chieh-Li Chen¹  Qinqin Zhang⁴  Chen Xin³  Rei Kono⁴  Murray A. Johnstone²  Philip P. Chen²  Karine D. Bojikian²  Divakar Gupta²  Joanne C. Wen²  Raghu C. Mudumbai² 

[1] Department of Bioengineering, Department of Ophthalmology, University of Washington, Seattle, WA, USA;Department of Ophthalmology, University of Washington, Seattle, WA, USA;;Department of Bioengineering,Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;Department of Bioengineering,

关键词: Optical coherence tomography angiography;    optical microangiography (OMAG);    primary open-angle glaucoma (POAG);    optic nerve head perfusion;   

DOI  :  10.21037/qims.2016.03.05

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Background: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.

Methods: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. En face OMAG images for preLC were generated using signals with highest blood flow signal intensity. ONH perfusion was quantified as flux, vessel area density, and normalized flux within the ONH. Standard t-tests were performed to analyze the ONH perfusion differences between normal and glaucomatous eyes. Linear regression models were constructed to analyze the correlation between ONH perfusion and other clinical measurements.

Results: Twenty normal and 21 glaucoma subjects were enrolled. Glaucomatous eyes had significantly lower ONH perfusion in preLC in all three perfusion metrics compared to normal eyes (P�?0.0003). Significant correlations between ONH perfusion and disease severity as well as structural changes were detected in glaucomatous eyes (P�?0.012).

Conclusions: ONH perfusion detected by OMAG showed significant differences between glaucoma and normal controls and was significantly correlated with disease severity and structural defects in glaucomatous eyes. ONH perfusion measurement using OMAG may provide useful information for detection and monitoring of glaucoma.

【 授权许可】

Unknown