Total gadolinium tissue deposition and skin structural findings following the administration of structurally different gadolinium chelates in healthy and ovariectomized female rats

Quantitative Imaging in Medicine and Surgery

Nathalie Fretellier¹  Sameh K. Morcos⁴  Jean-Marc Idée¹  Heiko Siegmund²  Gaëlle Jestin-Mayer¹  Yì-Xiáng J. Wáng⁵  Cecile Factor¹  Min Deng⁵  Wei Kang³  Joseph Schroeder² 

[1] Guerbet, Research and Innovation Division, BP 57400, 95943 Roissy-Charles de Gaulle cedex, France;Central EM Laboratory, Institute of Pathology, Uniklinikum Regensburg, The University of Regensburg, Germany;Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong SAR, China;;Department of Diagnostic Imaging, The University of Sheffield, Sheffield, UKDepartment of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong SAR, China;

关键词: Gadolinium (Gd);    skin;    ultrastructural;    bone deposition;    osteoporosis;   

DOI  :  10.3978/j.issn.2223-4292.2015.05.03

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Objective: To assess the retention of gadolinium (Gd) in skin, liver, and bone following gadodiamide or gadoteric acid administration.

Methods: Gd was measured in skin, liver and femur bone in female rats 10 weeks after administration of 17.5 mmol Gd/kg over 5 days of Gd agents. Rat skin microscopy, energy filtering transmission electron microscopy and elemental analysis were performed, and repeated after receiving the same dosage of gadodiamide in rats with osteoporosis induced with bilateral ovariectomy (OVX). The OVX was performed 60 days after the last injection of gadodiamide and animals sacrificed 3 weeks later.

Results: Gd concentration was 180-fold higher in the skin, 25-fold higher in the femur, and 30-fold higher in the liver in rats received gadodiamide than rats received gadoteric acid. The retention of Gd in the skin with gadodiamide was associated with an increase in dermal cellularity, and Gd encrustation of collagen fibers and deposition inside the fibroblasts and other cells. No differences in Gd concentration in liver, skin, and femur were observed between rats receiving gadodiamide with or without OVX.

Conclusions: Gd tissue retention with gadodiamide was higher than gadoteric acid. Tissues Gd deposition did not alter following gadodiamide administration to ovariectomized rats.

【 授权许可】

Unknown