Anterior segment optical coherence tomography evaluation of ocular graft-versus-host disease: a case study

Quantitative Imaging in Medicine and Surgery

Ruikang K. Wang²  Sepideh Hariri⁴  Stephanie J. Lee³  Peng Li⁴  Zhehai Zhou⁴  Yichen Sun¹  Tueng T. Shen²  Yoshihiro Inamoto³ 

[1] Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA;Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan;Department of Bioengineering,Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA;;Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA;Department of Bioengineering,

关键词: Medical and biological imaging;    optical coherence tomography (OCT);    ophthalmology;    ocular graft-versus-host disease (GVHD);   

DOI  :  10.3978/j.issn.2223-4292.2014.11.05

学科分类：外科医学

来源: AME Publications

【 摘 要 】

To explore ocular graft-versus-host disease (GVHD), anterior segment optical coherence tomography (AS-OCT) imaging of eyelids, tear meniscus, cornea and conjunctiva is performed in subsequent sessions on a patient who has ocular GVHD after allogeneic related donor stem cell transplant. The OCT results are presented together with those from a normal subject. OCT imaging is promising in visualizing several ocular GVHD manifestations, such as abnormal meibomian gland orifice (MGO), conjunctival keratinization, conjunctival hyperemia and chemosis, corneal epithelium opacification, thinning and sloughing. This case study demonstrates the capability of AS-OCT in the imaging and monitoring of ocular GVHD, which may be useful in the development of current ocular GVHD staging system and the clinical management for GVHD treatment.

【 授权许可】

Unknown