Automatic functional analysis of left ventricle in cardiac cine MRI

Quantitative Imaging in Medicine and Surgery

Graham A. Wright²  Alexander J. Dick⁴  Kim A. Connelly¹  Perry E. Radau³  Ying-Li Lu³ 

[1] Keenan Research Centre in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital and University of Toronto, Toronto, ON, Canada;Cardiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;;Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;Medical Biophysics, University of Toronto, ON, CanadaImaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada;

关键词: Left ventricular ejection fraction;    left ventricular mass (LVM);    cardiac magnetic resonance imaging;    automated border detection;    image processing;   

DOI  :  10.3978/j.issn.2223-4292.2013.08.02

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Rationale and objectives: A fully automated left ventricle segmentation method for the functional analysis of cine short axis (SAX) magnetic resonance (MR) images was developed, and its performance evaluated with 133 studies of subjects with diverse pathology: ischemic heart failure (n=34), non-ischemic heart failure (n=30), hypertrophy (n=32), and healthy (n=37).

Materials and methods: The proposed automatic method locates the left ventricle (LV), then for each image detects the contours of the endocardium, epicardium, papillary muscles and trabeculations. Manually and automatically determined contours and functional parameters were compared quantitatively.

Results: There was no significant difference between automatically and manually determined end systolic volume (ESV), end diastolic volume (EDV), ejection fraction (EF) and left ventricular mass (LVM) for each of the four groups (paired sample t-test, α=0.05). The automatically determined functional parameters showed high correlations with those derived from manual contours, and the Bland-Altman analysis biases were small (1.51 mL, 1.69 mL, �?0.02%, �?0.66 g for ESV, EDV, EF and LVM, respectively).

Conclusions: The proposed technique automatically and rapidly detects endocardial, epicardial, papillary muscles�? and trabeculations�? contours providing accurate and reproducible quantitative MRI parameters, including LV mass and EF.

【 授权许可】

Unknown