Quantitative MRI techniques of cartilage composition

Quantitative Imaging in Medicine and Surgery

Garry E. Gold¹  Jasper van Tiel³  Edwin H. G. Oei²  Stephen J. Matzat⁴ 

[1] Department of Radiology, Stanford University, CA, USA;Department of Orthopedic Surgery, Stanford University, CA, USA;Department of Bioengineering, Stanford University, CA, USADepartment of Radiology, Stanford University, CA, USA;Department of Radiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands;Department of Radiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands;Department of Orthopedic Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands;Department of Radiology, Stanford University, CA, USA;

关键词: Magnetic resonance imaging;    cartilage;    quantitative;    biomarker;    osteoarthritis (OA);   

DOI  :  10.3978/j.issn.2223-4292.2013.06.04

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Due to aging populations and increasing rates of obesity in the developed world, the prevalence of osteoarthritis (OA) is continually increasing. Decreasing the societal and patient burden of this disease motivates research in prevention, early detection of OA, and novel treatment strategies against OA. One key facet of this effort is the need to track the degradation of tissues within joints, especially cartilage. Currently, conventional imaging techniques provide accurate means to detect morphological deterioration of cartilage in the later stages of OA, but these methods are not sensitive to the subtle biochemical changes during early disease stages. Novel quantitative techniques with magnetic resonance imaging (MRI) provide direct and indirect assessments of cartilage composition, and thus allow for earlier detection and tracking of OA.

【 授权许可】

Unknown