Design considerations for targeted optical contrast agents

Quantitative Imaging in Medicine and Surgery

Gloria H. Hong¹  Jungmun Choi¹  Hak Soo Choi¹  Gwangli Park¹  Jeong Heon Lee¹ 

[1] Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;

关键词: Near-infrared imaging;    optical imaging;    targeted contrast agent;    biodistribution;   

DOI  :  10.3978/j.issn.2223-4292.2012.12.04

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Abstract

Optical fluorescence imaging with the right combination of imaging modality and targeted contrast agents offers tremendous improvement in intraoperative imaging and clinical output (i.e., image-guided cancer surgery). Therefore, it is of paramount importance to gain an in-depth knowledge in the design of targeted contrast agents to meet clinical requirements. Currently, there are several clinically approved contrast agents available; however, none perform optimally by providing optimum sensitivity, stability, specificity, and safety for target imaging, diagnosis, and therapy. In this review, we discuss basic design considerations for targeted contrast agents in terms of optical and physicochemical properties, biological and physiological interactions, and biodistribution and targeting.

【 授权许可】

Unknown