Hematobiochemical changes of lead Poisoning and amelioration with Coconut ( Cocos nucifera L.) Water in wistar albino rats

Journal of Applied Sciences and Environmental Management

IGIEHON , NICHOLAS OZEDE¹  IYORAH ,IMEDA EBIKERE¹  AIMUANMWOSA ,FRANK EGHOMWANRE¹  ENAGBONMA ,BEN JESUORSEMWEN¹ 

关键词: Albino rats;    Cocus nucifera L;    Lead toxicity;    Amelioration;    Haematobiochemical;   

DOI  :  

学科分类：环境科学（综合）

来源: University of Port Harcourt * Department of Pure and Industrial Chemistry

【 摘 要 】

To determine the ameliorative effect of coconut water on haematobiochemicalchanges due to lead poisoning in wistar albino rats for six weeks, sixty rats were assigned tofour groups. 0.10g/l of lead and 75ml coconut ( cocus nuciferal.) water were given orally for sixweeks. The mean values of red blood cells, mean corpuscular volume, mean corpuscularhaemoglobin, mean corpuscular haemoglobin concentration, red blood cell distribution widthand platelets (8.10±0.63(×106μl), 52.7±0.87(μm3), 17.9±0.56(pg), 34.73±0.65(g/dl),17.90±0.67(%) and 670.00±42.22(×103μl) respectively) reduced in lead treated rats whencompared with control mean values (8.41 ± 0.90(×106μl), 56.60 ± 1.55(μm3), 19.33 ± 0.82(pg),34.93 ± 0.90(g/dl), 18.27 ± 0.73(%) and 818.33± 123.68(×103μl) respectively ) and these valuesincreased in75ml coconut water only group and the group of 0.10g/l lead + 75ml coconut waterexcept mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, and redblood cell distribution width of the 75ml coconut water only. The mean values of white bloodcells, lymphocytes, total cholesterol, triglyceride, high density lipoprotein-cholesterol, lowdensity lipoprotein-cholesterol, low density lipoprotein-cholesterol/high density lipoproteincholesteroland total cholesterol/high density lipoprotein-cholesterol increased(12.23±0.57(×103μl), 79.83±3.87(%), 64.66±6.01(mg/dl), 89.00±7.94(mg/dl),22.67±6.93(mg/dl), 21.00±4.58(mg/dl), 1.29±0.62 and 3.36±0.83 respectively ) in the leadgroup when compared with mean values of control group (5.83±0.74(×103μl), 69.07±10.57(%),54.00±4.04(mg/dl), 97.33±11.34(mg/dl), 20.00±3.06(mg/dl), 17.00±6.51(mg/dl), 0.97±0.41 and2.87±0.55 respectively) but the mean values decreased when compared with the mean values ofgroup of 75ml coconut water only and group of 0.10g/l lead + 75ml coconut water, except themean values of high density lipoprotein-cholesterol. These results indicate that coconut watercould ameliorate effects of lead toxicity

【 授权许可】

Unknown