Investigation of the Effect of Alkali Modification of Mucin on Some Properties of Metronidazole Bioadhesive Tablets

Journal of Applied Sciences and Environmental Management

IWUAGWU, M.A.¹  ARHEWOH, M.I.¹  OKOGBENIN, C.O.¹  ERAGA, S.O.¹ 

关键词: alkali treatment;    mucin;    mucoadhesion;    tablets;    metronidazole;   

DOI  :  

学科分类：环境科学（综合）

来源: University of Port Harcourt * Department of Pure and Industrial Chemistry

【 摘 要 】

The objective of this study was to investigate the effect of alkali treatment ofmucin on the mucoadhesive properties and tablet parameters of metronidazole tablets. Mucinwas extracted from the African giant snails (Archachatina maginata) by differentialprecipitation using acetone, air-dried and pulverized. Different portion of the mucin powderwas treated with mineral bases (sodium and ammonium hydroxides) and organic base(pyridine) at high and low concentrations and at varied times of 1 and 12 h. Ten batches ofmetronidazole tablets (B1-B10) were prepared with the modified mucin by directcompression. Their granules and tablets were evaluated for flow properties and tabletsparameters, respectively. Tablet mucoadhesion was determined using the mass flow ratemethod. All the batches of granules gave good flow characteristics with their angles of repose< 30°. The formulated tablets passed the weight variation test and had hardness values withinthe range of 3.2 to 5.0 kp and friability of 0.7 to 2.0 % while the content of active drug metofficial compendial requirements. Tablets of 1 M NaOH treated mucin for 1 h gave the bestmucoadhesion values of 5.95 g/sec, followed by the 0.1 M NaOH 12 h treatment and 0.1 MNaOH 1 h treatment with 4.34 g/sec and 4.14 g/sec, respectively. These values were higherthan those of the unmodified mucin tablets which gave 0.75 g/sec. Tablets of 0.1M pyridinetreated mucin for 1 h gave the least mucoadhesion values of 0.51 g/sec. Tablets of mucintreatment using NaOH gave improved mucoadhesive properties compared to the unmodifiedmucin. Thus, NaOH modified mucin can be preferred in the formulation of somemucoadhesive dosage forms.

【 授权许可】

Unknown