Some Physical Properties of Vernonia amygdalina and Garcinia kola Microspheres Prepared with High Molecular Weight Polyethylene Glycols

Journal of Applied Sciences and Environmental Management

ARHEWOH, M.I.¹  IVUONGBE, F.E.¹  EZE, H.O.¹  ERAGA, S.O.¹ 

关键词: PEG;    microspheres;    V. amygdalina;    G. kola;    flavonoid;    physiochemical;   

DOI  :  

学科分类：环境科学（综合）

来源: University of Port Harcourt * Department of Pure and Industrial Chemistry

【 摘 要 】

The effect of polymer concentrations on some of the physicochemicalproperties of Vernonia amygdalina(Linn) and Garcinia kola(Heckel) extracts loadedmicrospheres was evaluated. Microspheres of the aqueous extracts was prepared by emulsionsolvent evaporation using polyethylene glycol (PEG) mixtures of molecular weight 4000 and6000 at different ratios of 1:0, 0:1, 1:1, 1:2 and 2:1 while the amounts of the extractsincorporated was constant for all ratios. The microspheres were evaluated for their particlessizes, yield, flavonoid content, loading efficiency, moisture loss and flow properties. In-vitrorelease studies were carried out by monitoring flavonoid release rate from the microspheres.The microspheres were spherical and uniformly shaped and exhibited good flowcharacteristics. Their size range, yield, loading efficiency, moisture loss and flavonoid contentwere 76 - 83 μm, 49 - 76 %, 47 - 82 %, 2.18 - 4.60 % and 17.10 - 23.80 mg%, respectivelyfor V. amygdalina and 144 - 160 μm, 50 - 68 %, 51 - 68 %, 3.00 - 4.41 % and 20.00 - 28.70mg%, respectively for G. kola. Flavonoids release from the microsphere was up to 90 %within 1 h and it followed a matrix release kinetic model with a super case-II transportmechanism. The concentrations of the polymers affected the yield, loading efficiency,moisture loss and the extent of flavonoid release of the microspheres but had no effect ontheir particle sizes and flavonoid content. These results may find useful application in thedelivery of V. amygdalina and G. kola extracts since the combination of PEG of differentmolecular weights resulted in microspheres with good physicochemical and releaseproperties.

【 授权许可】

Unknown