Synthesis and Biological Activities of Some Benzimidazoles Derivatives

Journal of Applied Sciences and Environmental Management

Al-Ebaisat, Hamdan S.¹ 

关键词: Benzimidazole;    Antifungal Agent;    Fungicides;    Aldehyde;    Derivative;    Chemical Synthesis.;   

DOI  :  

学科分类：环境科学（综合）

来源: University of Port Harcourt * Department of Pure and Industrial Chemistry

【 摘 要 】

A set of six novel benzimidazoles compounds were prepared, this includes 5-Nitro-2-phenyl -1-ethylbenzimidazol (5),2-(p-Bromophenyl)-5-nitro-1-ethylbenzimidazol (6), 2- (p-Bromophenyl- 5-nitro-1–cyclopentylbenzimidazol(7),2-(p-Bromophenyl)-5-nitro-1-cyclopentylbenzimidazol (8),5-Amino-2-(p-Bromophenyl)-1-ethylbenzimidazol (9), and 5-Amino-(2- (p- Bromophenyl)- 1- cyclopentylbenzimidazol (10). The chemical structures of thesecompounds were elucidated using NMR and elemental analysis. The biological activity of thesecompounds as fungicides was tested against three commercially known fungicides ( Candida albicans ,patient isolate Candida glabrataand Candida krusei ).The biological activity of two compounds was found to becomparable to that of the commercially available fungicides (6 and 9).

【 授权许可】

Unknown