Ground Organic Monolith Particles Having a Large Volume of Macropores as Chromatographic Separation Media

Bulletin of the Korean chemical society

Yune Sung Kim¹  Faiz Ali¹  Won Jo Cheong¹  Jin Wook Lee¹ 

关键词: Organic monolith particles;    Packed column;    Polyethylene glycol;    Macropores;    High pore volume;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A reaction mixture was developed for formation of soft organic monolith that was easily smashed, rinsed, refluxed, filtered, and dried to give monolith particles having high pore volume of macropores. This phase was almost without mesopores. The reaction mixture was composed of methacrylic acid, ethylene glycol dimethacrylate, polyethylene glycol (porogen), and an initiator in a mixed solvent of toluene and isooctane. The selection of porogen and its amount was carefully carried out to obtain the optimized separation efficiency of the resultant phase. The median macropore size was 1.6 μm, and the total pore volume was 3.0-3.4 mL/g. The median particle size (volume based) was 15 μm, and the range of particle size distribution was very broad. Nevertheless the column (1 × 300 mm) packed with this phase showed good separation efficiency (N~10,000- 16,000) comparable to that of a commercial column packed with 5 μm C18 silica particles.

【 授权许可】

Unknown