A Facile and Efficient Synthesis of Dronedarone Hydrochloride

Bulletin of the Korean chemical society

Jun Wu¹  Chunhua Jin¹  Feng Li¹  Jianwei Zou¹ 

关键词: Dronedarone;    Tandem-type synthesis;    Cyclization;    CO2 fixation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A facile and efficient synthesis of dronedarone hydrochloride starting from commercially available 4- nitrophenol is described. This approach features a tandem-type synthesis of 3-carbonylated benzofuran involving cyclization of 2-ethynylphenol followed by CO2 fixation at the 3-position of the benzofuran ring mediated by potassium carbonate without the addition of any transition metal catalyst.

【 授权许可】

Unknown