期刊论文详细信息
Bulletin of the Korean chemical society
A Facile and Efficient Synthesis of Dronedarone Hydrochloride
Jun Wu1  Chunhua Jin1  Feng Li1  Jianwei Zou1 
关键词: Dronedarone;    Tandem-type synthesis;    Cyclization;    CO2 fixation;   
DOI  :  
学科分类:化学(综合)
来源: Korean Chemical Society
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【 摘 要 】

A facile and efficient synthesis of dronedarone hydrochloride starting from commercially available 4- nitrophenol is described. This approach features a tandem-type synthesis of 3-carbonylated benzofuran involving cyclization of 2-ethynylphenol followed by CO2 fixation at the 3-position of the benzofuran ring mediated by potassium carbonate without the addition of any transition metal catalyst.

【 授权许可】

Unknown   

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