Synthesis, Anticancer and Antioxidant Activity of Novel 2,4-Disubstituted Thiazoles

Bulletin of the Korean chemical society

Jung-Ae Kim¹  Mi Yeong Kim¹  Mungara Anil Kumar¹  Seung Hyun Chang¹  Kap Duk Lee¹  Tran Nguyen Minh An¹ 

关键词: 2;    4-Disubstituted thiazole;    Carbazole;    -Bromoketone;    Cytotoxicity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A new series of carbazole based 2,4-disubstituted thiazole derivatives were synthesized. All the synthesized compounds were tested for their cytotoxicity against three different cancer cell lines A549, MCF-7, and HT29. Some of these compounds showed good cytotoxicity. These compounds were also evaluated for antioxidant activity. Compounds 3a, 3b, 3d-f and 3i showed higher antioxidant activity than standard BHT.

【 授权许可】

Unknown