Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives

Bulletin of the Korean chemical society

Yang-Gen Hu¹  Jing Wu¹  Erli Zhang¹  Qiu-Fei Hou¹  Yan-Ling Wang¹  Zai-Fang Li¹  Ping He¹  Kun Zhao¹ 

关键词: Pyrrolo[3;    2-d]pyrimidine;    Aza-Wittig reaction;    Iminophosphorane;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5- dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate and aromatic isocyanates, followed by addition of amines/phenols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.

【 授权许可】

Unknown