A New Flavonol Glycoside from the Leaves of Boscia senegalensis

Bulletin of the Korean chemical society

Young Ho Kim¹  Sang Kyum Kim¹  Abubaker M. A. Morgan¹  Jang Hoon Kim¹  Chi-Hwan Lim¹ 

关键词: Boscia senegalensis;    Capparaceae;    Flavonol glycoside;    Soluble epoxide hydrolase;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Detailed chemical investigation of Boscia senegalensis (Per) Lam. ex Poir. led to the isolation of one new flavonol glycoside, rhamnocitrin-3-O-β-D-(6``-O-E-feruloyl)-glucopyranoside named bosenegaloside A (1), with seven known compounds, rhamnocitrin-3-O-β-D-(6``-O-E-p-coumaroyl)-glucopyranoside (2), rhamnocitrin- 3-O-β-D-glucopyranoside (3), 3,4,5-trimethoxyphenol-β-D-glucopyrinoside (4), lasianthionoside A (5), 3,7- dimethyl-1-octene-3,6,7-triol-6-O-β-D-glucopyranoside (6), syringin (7), and austroside B (8). The chemical structures of these compounds were elucidated from spectroscopic data and by comparison of these data with previously published results. The inhibitory activity of the isolated compounds on soluble epoxide hydrolase (sEH) was assessed. Compounds 1-3 potently inhibited sEH activity with IC50 values of 12.8 ± 0.5, 18.4 ± 0.2, and 11.3 ± 0.9 μM, respectively.

【 授权许可】

Unknown