C–H Arylation of Nitroimidazoles and Nitropyrazoles Guided by the Electronic Effect of the Nitro Group

Bulletin of the Korean chemical society

Jung Min Joo¹  Seri Bae¹  Haeun Jung¹  Ha-Lim Jang¹ 

关键词: C–H arylation;    Nitroimidazole;    Nitropyrazole;    Palladium;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A palladium-catalyzed C–H arylation reaction of nitroimidazoles and nitropyrazoles was developed using aryl bromides as arene donors. The electron-withdrawing effect of the nitro group allows for direct C–H arylation reactions of the nitro diazoles with high regioselectivity under mild conditions. The new C–H arylation approach is thus complementary to nucleophilic substitution reactions, enabling the preparation of complex nitroazole compounds.

【 授权许可】

Unknown