Bulletin of the Korean chemical society | |
Synthesis and Preliminary Cytotoxicity Evaluation of New Diarylamides and Diarylureas Possessing 2,3-Dihydropyrrolo[3,2-b]quinoline Scaffold | |
Yong Sup Lee1  Mohammed I. El-Gamal1  Chang-Hyun Oh1  Hyun-Jin Kim1  | |
关键词: 2; 3-Dihydropyrrolo[3; 2-b]quinoline; Urea; Amide; Antiproliferative activity; Breast cancer; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
A new series of diarylamides and diarylureas having 2,3-dihydropyrrolo[3,2-b]quinoline scaffold was synthesized. Their in vitro antiproliferative activities were tested over NCI-60 cancer cell lines of nine different cancer types. Some target compounds showed good inhibition percentages over different cell lines. Among all the target compounds, compound 1f possessing 6,7-dimethoxy-2,3-dihydropyrrolo[3,2-b]quinoline nucleus, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed high selectivity against MCF7 and MDAMB- 468 breast cancer cell lines more than the other tested cell lines. Its inhibition percentages at 10 μM concentration over those two cell lines were 84.97% and 87.13%, respectively.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010244721ZK.pdf | 703KB | download |