Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)

Bulletin of the Korean chemical society

Hyun-Sun Yang¹  Sang-Hun Jung¹  Ki-Cheul Lee¹  Niti Sharma¹  Vinay K. Sharma¹  Seong-Cheol Bang¹ 

关键词: Arylsulfonylimidazolidinone;    Solubility;    Cytotoxicity;    Anti-cancer;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)- phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline- 1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.

【 授权许可】

Unknown