Optimization of the Reaction Conditions for Synthesis of 3-(Aryloxy)quinoline Derivatives via Friedländer’s Cyclization Reaction

Bulletin of the Korean chemical society

Mohammad Ashrafuddin Khan¹  Mohammed I. El-Gamal¹  Chang-Hyun Oh¹ 

关键词: Cyclization reaction;    2-Amino-4;    5-dimethoxybenzaldehyde;    Friedländer’s reaction;    Quinoline;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

6,7-Dimethoxy-2-methyl-3-(4-nitrophenoxy)quinoline was synthesized by Friedländer’s cyclization reaction. Different bases and solvents were tested in order to optimize the reaction conditions. The highest yields were obtained using piperidine in refluxing ethanol. Further reactions were carried out in order to prepare different diarylamide and diarylurea derivatives in moderate to high yields in order to examine their anticancer activities.

【 授权许可】

Unknown