Synthesis of Ergosterol and 5,6-Dihydroergosterol Glycosides and Their Inhibitory Activities on Lipopolysaccharide-Induced Nitric Oxide Production

Bulletin of the Korean chemical society

Hakwon Kim¹  Tae Hoon Lee¹  Jiyoung Kim¹  Fei Chang¹  HoonGyu Park¹  Hyun Ji Kwon¹ 

关键词: Glycosyl ergosterol;    Glycosyl 5;    6-dihydroergosterol;    Glycosylation;    Inhibitory activity;    NO production;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

We have synthesized several glycosyl ergosterols and 5,6-dihydroergosterols (DHE) and examined their effects on production of nitric oxide (NO) and iNOS protein expression in LPS-treated RAW264.7 macrophage cells. Our results showed that DHE derivatives inhibited production of NO and iNOS protein expression more strongly than ergosterol derivative. Especially, DHE-Glc exhibited most potent inhibitory activity without cytotoxicity up to the concentration of 100 μM.

【 授权许可】

Unknown