A Total Synthesis of Aliskiren Starting from D-Tartrate Diester

Bulletin of the Korean chemical society

Ji Hei Kim¹  Soo Y. Ko¹ 

关键词: Aliskiren;    Total synthesis;    D-tartrate diester;    Symmetric precursor;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid- cis-bis-lactone 3` as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.

【 授权许可】

Unknown