Deuterium Naturally Present in Solvent and Site-Specific Isotope Population of Deuterium-Enriched Solute

Bulletin of the Korean chemical society

Juhee Lee¹  Eun Hee Kim¹  Oc Hee Han¹  Ryeo Yun Hwang¹ 

关键词: NMR spectroscopy;    Deuterium;    Isotopes;    Alcohol;    Proton exchange;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

As the concentration of aqueous CD3OH solutions was decreased, the OD peaks in 2H NMR spectra grew relative to the CD3 peaks. Isotope impurity for OH groups of CD3OH and deuterium naturally present in water contributed to the OD peaks. Using these peak area data, the site-specific isotope populations of isotope enriched chemicals were measured. In addition, the method using both 1H and 2H NMR spectroscopy was demonstrated with neat CD3OH to measure the site-specific isotope populations. The results indicate that although it represents only ~0.015% of hydrogen isotopes, the deuterium naturally present in solvents cannot be ignored, especially when the concentration of deuterium-enriched solutes is varied. Proton/deuteron exchange between methyl and methyl/hydroxyl groups was confirmed to be negligible, while that among hydroxyl groups was detectable.

【 授权许可】

Unknown