Functionalization of Organotrifluoroborates via Cu-Catalyzed C-N Coupling Reaction

Bulletin of the Korean chemical society

a¹  Jung Ho Song¹  Heejin Kim¹  Jung-Hyun Lee¹  Won-Suk Kim¹  Jungyeob Ham¹  Taejung Kim¹ 

关键词: Organotrifluoroborate;    Potassium N-heterobiaryltrifluoroborates;    Cu-catalyzed C-N coupling;    Chan-Lam coupling;    N-Heterobiarene;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Potassium N-heterobiaryltrifluoroborates were successfully prepared via a selective Cu-catalyzed C-N coupling reaction. The BF3K moiety was well tolerated under the reaction conditions involving CuI and dimethylethylenediamine (DMEDA) in the presence of DMSO. The Pd-catalyzed Suzuki-Miyaura cross couplings of potassium N-heterobiaryltrifluoroborates with bromoarenes were studied to prepare the N-heterotriaryl compounds. Moreover, homocoupling, iodination, and hydroxylation of potassium N-heterobiaryltrifluoroborates provided the corresponding products in high yields.

【 授权许可】

Unknown