Ailanthoidol Derivatives and their Anti-inflammatory Effects

Bulletin of the Korean chemical society

Jong-Gab Jun¹  Jae Jun Lee¹  Na Li Lee¹  Jin-Kyung Kim¹ 

关键词: Ailanthoidol;    2-Arylbenzo[b]furan;    Anti-inflammatory;    Nitric oxide;    Iodine-induced cyclization;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Ailanthoidol showed a strong anti-inflammatory effect in a previous result. Ailanthoidol derivatives were prepared for the anti-inflammatory test using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared ailanthoidol derivatives were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that some ailanthoidol derivatives inhibited significantly the production of inflammatory mediator nitric oxide.

【 授权许可】

Unknown