Metabolic Pharmacokinetics in Rats: Differences between Pure Amygdalin and Amygdalin in a Decoction of Peach Seeds

Bulletin of the Korean chemical society

Xitao Yan¹  Jong Seong Kang¹  Young Ho Kim¹  Wonjae Lee¹  Kyung Tae Kim¹  Yong Ki Park¹  Young Keun Lee¹  Jianbo Chen¹  Sang Hyuck Kim¹  Tae Jin Kim¹  Cheong Weon Cho¹  Jongsuep Baek¹ 

关键词: Amygdalin;    Prunasin;    Peach seed;    High performance liquid chromatography;    Pharmacokinetic studies;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The pharmacokinetics of prunasin after oral administration of amygdalin or a decoction of peach seeds was determined and compared in rats. A C18 column was used for separation at a column temperature of 25 oC. The mobile phase consisted of 20% aqueous acetonitrile, and the flow rate was 0.5 mL/min. After oral administration of a decoction of peach seeds, prunasin was absorbed rapidly, reaching a maximum plasma concentration (Cmax) of 62.1 mg/L within 45 min. After oral administration of amygdalin, the absorption of prunasin was delayed. The Cmax of prunasin was 42.9 mg/L and was reached at 60 min. Values for the pharmacokinetic parameters of prunasin, including Tmax, Cmax, AUC, T1/2, CL/F, and V1/F, were significantly different for the oral administration of amygdalin compared with that of a decoction of peach seeds.

【 授权许可】

Unknown