Bulletin of the Korean chemical society | |
Preparation of CdSe QDs-carbohydrate Conjugation and its Application for HepG2 Cells Labeling | |
Meili Hu1  Yan Chen1  Mingxing Jiang1  Guiqing Kai1  Ruijun Wang1  Huali Cui1  | |
关键词: CdSe quantum dots; Carbohydrates molecules; HepG2 mannose receptor; Receptor-mediated endocytosis; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
In present study, CdSe quantum dots (QDs) were prepared with a novel but simple, effective and exercisable method. Nine different types of carbohydrate molecules were used to modify CdSe QDs. D-mannose (Man)- coated quantum dots were prepared for labeling human hepatoma (HepG2) cells, because of the high expression of mannose receptor (MR) on HepG2 cells. The uptake characteristics of CdSe QDs-Man were investigated in HepG2 cells. The absorption rate result of MTT assay in 48 h suggested the extremely low cytotoxicity of CdSe QDs-Man. The presence of quantum dots was confirmed with fluorescence microscopy. These results were encouraging regarding the application of QDs molecules for early detection of HepG2 cells.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912010243617ZK.pdf | 3465KB | download |