Radiosynthesis and Biodistribution of an 125I-labeled Resveratrol Derivative

Bulletin of the Korean chemical society

Eun Jung Kim¹  Woong San Lee¹  Sung Kew Kim¹  Jung-Hyuck Cho¹  In-Hye Ham¹  Byoung Soo Kim¹  Ho-Young Choi¹  Tae Hyun Choi¹  Chang Woon Choi¹  Mohammed I. El-Gamal¹  Chang-Hyun Oh¹  Sang Jin Han¹ 

关键词: Radiosynthesis;    Resveratrol;    Iodoresveratrol;    Biodistribution;    Imaging agent;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An 125I-labeled resveratrol derivative 1 was synthesized. It was purified by reverse phase HPLC. Radiochemical purity of the product was more than 98%, and the yield was 35% (decay-corrected). Its biodistribution in tumorbearing mice was studied. The results showed that the highest radioactivity was located in intestine and stomach. The biodistribution profile suggests that compound 1 can be effectively used as a promising imaging probe for intestine and stomach.

【 授权许可】

Unknown