Some Pyridyl- and Thiophenyl- Substituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Derivatives as Potent Antibacterial

Bulletin of the Korean chemical society

Aftab Ahmed Khan¹  Ki-Hwan Lee¹  Muhammad Rafiq¹  Muhammad Hanif¹  Sung-Yum Seo¹  Mazhar Iqbal¹  Muhammad Rizwan Maqsood¹  Muhammad Saleem¹  Jamshed Iqbal¹  Sumera Zaib¹  Nasim Hasan Rama¹ 

关键词: Triazolothiadiazoles;    Antibacterial activities;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.

【 授权许可】

Unknown