期刊论文详细信息
Bulletin of the Korean chemical society
Kinetics and Mechanistic Chemistry of Oxidation of Butacaine Sulfate by Chloramine-B in Acid Medium
Vinutha Kotabagi1  Puttaswamy1  Jayachamarajapura Pranesh Shubha1 
关键词: Butacaine sulfate;    Local anaesthetics;    Oxidation-kinetics;    Chloramine-B;    Acid medium;   
DOI  :  
学科分类:化学(综合)
来源: Korean Chemical Society
PDF
【 摘 要 】

Butacaine sulfate is an ester of p-aminobenzoic acid which has been widely used as a local anaesthetic and it is a long standing agent particularly for spinal anaesthesia. For this reason, a kinetic study of oxidation of butacaine sulfate by sodium N-chlorobenzenesulfonamide (chloramine-B or CAB) has been carried out in HClO4 medium at 303 K in order to explore this redox system mechanistic chemistry. The rate shows a firstorder dependence on both [CAB]o, and [substrate]o, and a fractional-order dependence on acid concentration. Decrease of dielectric constant of the medium, by adding methanol, increases the rate of the reaction. Variation of ionic strength and addition of benzenesulfonamide or NaCl have no significant effect on the rate. The reaction was studied at different temperatures and the activation parameters have been evaluated. The stoichiometry of the reaction has been found to be 1:2 and the oxidation products have been identified by spectral analysis. The observed results have been explained by plausible mechanism and the related rate law has been deduced.

【 授权许可】

Unknown   

【 预 览 】
附件列表
Files Size Format View
RO201912010243451ZK.pdf 220KB PDF download
  文献评价指标  
  下载次数:9次 浏览次数:7次