Solid-phase Parallel Synthesis of a Novel N-[Alkylsulfonamido-spiro(2H-1-benzopyran- 2,4-piperidine)-6-yl] substituted Amide and Amine Drug-like Libraries

Bulletin of the Korean chemical society

Young-Dae Gong¹  Gee-Hyung Lee¹  Jin-soo Seo¹  Ji-Hye Kim¹ 

关键词: Spiro(2H-1-benzopyran-2;    4-piperidine)-6-yl derivatives;    Solid-phase parallel synthesis;    Druglike benzopyran core skeleton;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

We report the solid-phase library construction of 222 number of a novel N-[alkyl sulfonamido-spiro(2H-1- benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B derivatives. The polymer-bound N- [alkylsulfonamido-spiro(2H-1-benzopyran-2,4-piperidine)-6-yl] substituted amide 9 and amine 10 derivatives were obtained by first diversity generation with various acid chlorides and alkyl halides. Further reactions on the resins 9 and 10 with substituted sulfonyl chlorides produced the desired N-[alkylsulfonamido-spiro(2H-1- benzopyran-2,4-piperidine)-6-yl] substituted amide 1A and amine 1B analogues.

【 授权许可】

Unknown