Inhibitory Effect of 4-aryl 2-Substituted Aniline-thiazole Analogs on Growth of Human Prostate Cancer LNCap Cells

Bulletin of the Korean chemical society

Kyung-Chae Jeong¹  Kwang Hwa Park¹  ¶ Bae Keun Park¹  Nam Sook Kang$¹  Seong Hwan Kim¹  Nakjeong Kim¹  Seung-hwa Baek¹ 

关键词: Androgen receptor;    Antagonist;    LNCap cell;    Prostate cancer;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Androgen receptor (AR) is ligand-inducible nuclear hormone receptor which has been focused on key molecular target in growth and progression of prostate cancer. We synthesized a series of 4-aryl 2-substituted aniline-thiazole analogs and evaluated their anti-cancer activity in AR-dependent human prostate cancer LNCap cells. Among them, the compound 6 inhibited the tumor growth in LNCap-inoculated xenograft model.

【 授权许可】

Unknown