Synthesis of Halicylindramide A Mimetics Containing Lactone Isosteres

Bulletin of the Korean chemical society

Dongyeol Lim¹  Hyunju Seo¹  Sanghyuk Yeo¹ 

关键词: Synthesis;    Halicylindramide A;    Mimetic;    Depsipeptide;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Synthesis of halicylindramide A mimetics via solid-phase peptide synthesis is described. The N-Me-Gly-Thr residues in halicyclindramide A has been replaced by N-Me-Gly-Dpr, Lys, or N-Me-Gly-allo-Thr. Solution structures of the mimetics were compared by CD spectroscopy in an aqueous buffer and in TFE.

【 授权许可】

Unknown